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Inventi Impact: Anaesthesiology

Articles

  • Inventi:haa/13/12
    MECHANISM OF ANESTHETIC TOXICITY:METABOLISM, REACTIVE OXYGEN SPECIES, OXIDATIVE STRESS, AND ELECTRON TRANSFER
    31-Dec-2011 Review 2012 : January - March
    Peter Kovacic, Ratnasamy Somanathan

    There is much literature on the toxic effects of anesthetics. This paper deals with both the volatiles and locals. Adverse effects\r\nappear to be multifaceted, with the focus on radicals, oxidative stress (OS), and electron transfer (ET). ET functionalities involved\r\nare quinone, iminoquinone, conjugated iminium, and nitrone. The non-ET routes involving radicals and OS apparently pertain\r\nto haloalkanes and ethers. Beneficial effects of antioxidants, evidently countering OS, are reported. Knowledge at the molecular\r\nlevel should aid in devising strategies to combat the adverse effects.

    How to Cite this Article
    CC Compliant Citation: Peter Kovacic and Ratnasamy\r\nSomanathan, â??Mechanism of Anesthetic Toxicity: Metabolism,\r\nReactive Oxygen Species, Oxidative Stress, and Electron\r\nTransfer,â? ISRN Anesthesiology, vol. 2011, Article ID 402906, 10\r\npages, 2011. doi:10.5402/2011/402906.
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